Provincial police responded to a two-vehicle collision at Oxford Road 29 and Oxford Road 22 in Blandford-Blenheim Township.
Police say the collision involving an SUV and a motorcycle happened around 4 p.m. Thursday.
The man operating the motorcycle was transported to hospital, but later died of his injuries.
The deceased has been identified by OPP as 25-year-old Ryan Gopsill of Innerkip.
That intersection remained closed for several hours Thursday afternoon, but has since reopened.
The driver of the SUV was not injured.
Police say the cause of the collision is not known at this time, and the investigation is ongoing.
UPDATE: #OPP Oxford County still on scene advising collision is a single fatality involving a motorcycle and an SUV, roads are closed while emergency crews on scene, roads will open soon^pc— OPP West Region (@OPP_WR) September 3, 2020